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Issue 51, 2012
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Fluorescent probe for detection of bacteria: conformational trigger upon bacterial reduction of an azo bridge

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Abstract

Using biomimetic chemical reduction or Clostridium perfringens cell extract containing azoreductase, the dimer-fluorescent probe 2,4-O-bisdansyl-6,7-diazabicyclooct-6-ene, which possesses a conformationally constrained cis-azo bridge, is reduced to the tetra-equatorial 2,4-O-bisdansyl-cyclohexyl-3,5-bisammonium salt which exhibits fluorescence indicative of a dansyl monomer.

Graphical abstract: Fluorescent probe for detection of bacteria: conformational trigger upon bacterial reduction of an azo bridge

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Article information


Submitted
08 Apr 2012
Accepted
08 May 2012
First published
09 May 2012

Chem. Commun., 2012,48, 6393-6395
Article type
Communication

Fluorescent probe for detection of bacteria: conformational trigger upon bacterial reduction of an azo bridge

N. J. W. Rattray, W. A. Zalloum, D. Mansell, J. Latimer, C. H. Schwalbe, A. J. Blake, E. V. Bichenkova and S. Freeman, Chem. Commun., 2012, 48, 6393
DOI: 10.1039/C2CC32521G

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