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Issue 57, 2012
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Hydrolytically stable octahedral silicon complexes as bioactive scaffolds: application to the design of DNA intercalators

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Abstract

We here introduce octahedral silicon serving as a structural center for the design of hydrolytically stable bioactive complexes as demonstrated with the generation of silicon-based high affinity DNA binders. This proof-of-principle study suggests that octahedral silicon complexes are falsely neglected, promising structural templates for widespread applications in chemical biology and medicinal chemistry.

Graphical abstract: Hydrolytically stable octahedral silicon complexes as bioactive scaffolds: application to the design of DNA intercalators

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Article information


Submitted
07 Apr 2012
Accepted
26 Apr 2012
First published
27 Apr 2012

Chem. Commun., 2012,48, 7131-7133
Article type
Communication

Hydrolytically stable octahedral silicon complexes as bioactive scaffolds: application to the design of DNA intercalators

Y. Xiang, C. Fu, T. Breiding, P. K. Sasmal, H. Liu, Q. Shen, K. Harms, L. Zhang and E. Meggers, Chem. Commun., 2012, 48, 7131
DOI: 10.1039/C2CC32506C

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