Issue 55, 2012
From the journal:

Chemical Communications

Logic circuit upon angiogenic response controlled by enzyme-linked iron oxide microparticles—towards biocomputing in human cells†

Kyung-Woo Kim,a   Yang Eon Kim,b   Vera Bocharova,c   Jan Halámek,c   Chang-Woo Lee,b   Evgeny Katzc  and  Min-Kyu Oh*a  

* Corresponding authors

a Department of Chemical and Biological Engineering, Korea University, Seoul 136-713, Republic of Korea
E-mail: mkoh@korea.ac.kr
Fax: +82-2-926-6102
Tel: +82-2-3290-4850

b Battelle-Korea, Techno Complex Research Center, Korea University, Seoul 136-713, Republic of Korea

c Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA

Abstract

In the present study, we designed a logic circuit upon angiogenic response controlled by a combination of enzyme-functionalized magnetic microparticles operating in human umbilical vein endothelial cells (HUVECs). The reported results represent the first example of a biocomputing system operating in controlling angiogenesis.

Graphical abstract: Logic circuit upon angiogenic response controlled by enzyme-linked iron oxide microparticles—towards biocomputing in human cells

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Article information

DOI
https://doi.org/10.1039/C2CC32445H
Article type
Communication
Submitted
05 Apr 2012
Accepted
16 May 2012
First published
17 May 2012

Chem. Commun., 2012,48, 6918-6920

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Logic circuit upon angiogenic response controlled by enzyme-linked iron oxide microparticles—towards biocomputing in human cells

K. Kim, Y. E. Kim, V. Bocharova, J. Halámek, C. Lee, E. Katz and M. Oh, Chem. Commun., 2012, 48, 6918 DOI: 10.1039/C2CC32445H

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