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Issue 51, 2012
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Efficient, divergent synthesis of cryptophycin unit A analogues

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Abstract

A flexible and divergent synthesis of cryptophycin unit A analogues is described. This method relies on iridium-catalysed stereo- and enantioselective crotylation and chemoselective one-pot oxidative olefination to access common intermediate 8. Heck, cross metathesis, and Suzuki-Miyaura reactions are illustrated for the generation of methyl ester unit A analogues 10a–d.

Graphical abstract: Efficient, divergent synthesis of cryptophycin unit A analogues

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Supplementary files

Article information


Submitted
03 Apr 2012
Accepted
01 May 2012
First published
02 May 2012

Chem. Commun., 2012,48, 6414-6416
Article type
Communication

Efficient, divergent synthesis of cryptophycin unit A analogues

K. L. Bolduc, S. D. Larsen and D. H. Sherman, Chem. Commun., 2012, 48, 6414
DOI: 10.1039/C2CC32417B

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