Issue 52, 2012
From the journal:

Chemical Communications

Manganese(iii)-mediated radical cyclisations for the (Z)-selective synthesis of exo-alkylidene pyrrolidinones and pyrrolidines†

Harriet A. Keane,a   Wilfried Hessa  and  Jonathan W. Burton*a  

* Corresponding authors

a Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, UK
E-mail: jonathan.burton@chem.ox.ac.uk
Fax: +44 (0)1865 285002

Abstract

The cyclisation of alkynyl amido- and amino-malonates in the presence of manganese(III) acetate gives exo-alkylidene pyrrolidinones and pyrrolidines with a preference for the (Z)-alkene product isomer.

Graphical abstract: Manganese(iii)-mediated radical cyclisations for the (Z)-selective synthesis of exo-alkylidene pyrrolidinones and pyrrolidines

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Article information

DOI
https://doi.org/10.1039/C2CC32382F
Article type
Communication
Submitted
02 Apr 2012
Accepted
08 May 2012
First published
24 May 2012

Chem. Commun., 2012,48, 6496-6498

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Manganese(III)-mediated radical cyclisations for the (Z)-selective synthesis of exo-alkylidene pyrrolidinones and pyrrolidines

H. A. Keane, W. Hess and J. W. Burton, Chem. Commun., 2012, 48, 6496 DOI: 10.1039/C2CC32382F

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