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Issue 45, 2012
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In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

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Abstract

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

Graphical abstract: In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

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Article information


Submitted
06 Mar 2012
Accepted
17 Apr 2012
First published
01 May 2012

Chem. Commun., 2012,48, 5674-5676
Article type
Communication

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

D. Matthes, L. Richter, J. Müller, A. Denisiuk, S. C. Feifel, Y. Xu, P. Espinosa-Artiles, R. D. Süssmuth and I. Molnár, Chem. Commun., 2012, 48, 5674
DOI: 10.1039/C2CC31669B

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