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Issue 44, 2012
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Self-assembling DNA–peptide hybrids: morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide

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Abstract

For the very first time, highly efficient synthesis of DNA–peptide hybrids to scaffold self-assembled nanostructures is described. Oligonucleotide conjugation to the diphenylalanine dipeptide triggers a morphological transition from fibrillar to vesicular structures which may potentially be used as delivery vehicles, since they exhibit pH triggered release.

Graphical abstract: Self-assembling DNA–peptide hybrids: morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide

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Publication details

The article was received on 27 Feb 2012, accepted on 03 Apr 2012 and first published on 26 Apr 2012


Article type: Communication
DOI: 10.1039/C2CC31458D
Chem. Commun., 2012,48, 5440-5442

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    Self-assembling DNA–peptide hybrids: morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide

    N. Gour, D. Kedracki, I. Safir, K. X. Ngo and C. Vebert-Nardin, Chem. Commun., 2012, 48, 5440
    DOI: 10.1039/C2CC31458D

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