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Issue 35, 2012
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An ultrasensitive electrochemical DNA sensor based on the ssDNA-assisted cascade of hybridization reaction

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Abstract

We have developed a simple and ultrasensitive E-DNA sensor based on the ssDNA-assisted cascade of a hybridization reaction mechanism to form a long concatamers structure to improve its sensitivity, significantly. The proposed sensor was applied to sequence-specific DNA and ATP detection. Experimental results showed a quantitative measurement with the detection limit as low as 1 aM for specific DNA and 10 fM for ATP.

Graphical abstract: An ultrasensitive electrochemical DNA sensor based on the ssDNA-assisted cascade of hybridization reaction

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Supplementary files

Article information


Submitted
11 Feb 2012
Accepted
06 Mar 2012
First published
06 Mar 2012

Chem. Commun., 2012,48, 4208-4210
Article type
Communication

An ultrasensitive electrochemical DNA sensor based on the ssDNA-assisted cascade of hybridization reaction

B. Yin, Y. Guan and B. Ye, Chem. Commun., 2012, 48, 4208
DOI: 10.1039/C2CC30997A

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