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Issue 36, 2012
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Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones

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Abstract

We disclose an organocatalyzed enantioselective decarboxylative ketone aldol reaction of β-ketoacids with trifluoromethyl ketones in the presence of biscinchona alkaloid (DHQD)2AQN, affording chiral tertiary alcohols in up to 98% yield and 90% ee.

Graphical abstract: Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones

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Article information


Submitted
09 Feb 2012
Accepted
09 Mar 2012
First published
09 Mar 2012

Chem. Commun., 2012,48, 4308-4310
Article type
Communication

Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones

Y. Zheng, H. Xiong, J. Nie, M. Hua and J. Ma, Chem. Commun., 2012, 48, 4308
DOI: 10.1039/C2CC30949A

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