Issue 32, 2012

Preparation of quinazolino[3,2-a]quinazolines via a palladium-catalyzed three-component reaction of carbodiimide, isocyanide, and amine

Abstract

A palladium-catalyzed three-component reaction of bis-(2-iodoaryl)carbodiimide, isocyanide, and amine gives rise to quinazolino[3,2-a]quinazolines and related compounds in good yields. Multi-bonds are formed in one pot through nucleophilic attack, isocyanide insertion, and C–N coupling during the reaction process.

Graphical abstract: Preparation of quinazolino[3,2-a]quinazolines via a palladium-catalyzed three-component reaction of carbodiimide, isocyanide, and amine

Supplementary files

Article information

Article type
Communication
Submitted
09 Feb 2012
Accepted
27 Feb 2012
First published
28 Feb 2012

Chem. Commun., 2012,48, 3836-3838

Preparation of quinazolino[3,2-a]quinazolines via a palladium-catalyzed three-component reaction of carbodiimide, isocyanide, and amine

G. Qiu, Y. He and J. Wu, Chem. Commun., 2012, 48, 3836 DOI: 10.1039/C2CC30928A

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