Issue 87, 2012

I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

Abstract

I-motif formation has been confirmed in a number of gene promoter sequences known to form G-quadruplex structures. I-motif formation can occur close to physiological temperature and pH for h-tert and PDGF-A. The i-motif structure formed by a HIF-1α promoter sequence shows unexpected stability near neutral pH.

Graphical abstract: I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

Supplementary files

Article information

Article type
Communication
Submitted
07 Feb 2012
Accepted
28 May 2012
First published
29 May 2012

Chem. Commun., 2012,48, 10739-10741

I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

J. A. Brazier, A. Shah and G. D. Brown, Chem. Commun., 2012, 48, 10739 DOI: 10.1039/C2CC30863K

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