Issue 39, 2012
From the journal:

Chemical Communications

Photocaged permeability: a new strategy for controlled drug release†

M. Michael Dcona,ab   Deboleena Mitra,ab   Rachel W. Goehe,bc   David A. Gewirtz,bc   Deborah A. Lebmanbd  and  Matthew C. T. Hartman*ab  

* Corresponding authors

a Department of Chemistry, Virginia Commonwealth University (VCU), 1001 West Main Street, P. O. Box 842006, Richmond, USA
E-mail: mchartman@vcu.edu

b Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, USA

c Department of Pharmacology and Toxicology, VCU, Richmond, USA

d Department of Microbiology and Immunology, VCU, Richmond, USA

Abstract

Light is used to release a drug from a cell impermeable small molecule, uncloaking its cytotoxic effect on cancer cells.

Graphical abstract: Photocaged permeability: a new strategy for controlled drug release

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Article information

DOI
https://doi.org/10.1039/C2CC30819C
Article type
Communication
Submitted
05 Feb 2012
Accepted
07 Mar 2012
First published
08 Mar 2012

Chem. Commun., 2012,48, 4755-4757

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Photocaged permeability: a new strategy for controlled drug release

M. M. Dcona, D. Mitra, R. W. Goehe, D. A. Gewirtz, D. A. Lebman and M. C. T. Hartman, Chem. Commun., 2012, 48, 4755 DOI: 10.1039/C2CC30819C

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