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Issue 50, 2012
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Programmable proteinprotein conjugation via DNA-based self-assembly

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Abstract

Protein molecules were precisely arrayed on a designable DNA scaffold close to each other using a DNA aptamer. By adding a chemical cross-linker, the neighboring protein molecules were effectively and covalently cross-linked to each other without losing their activities.

Graphical abstract: Programmable protein–protein conjugation via DNA-based self-assembly

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Publication details

The article was received on 28 Jan 2012, accepted on 21 Feb 2012 and first published on 22 Feb 2012


Article type: Communication
DOI: 10.1039/C2CC30618B
Chem. Commun., 2012,48, 6226-6228

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    Programmable proteinprotein conjugation via DNA-based self-assembly

    J. Shimada, T. Maruyama, M. Kitaoka, H. Yoshinaga, K. Nakano, N. Kamiya and M. Goto, Chem. Commun., 2012, 48, 6226
    DOI: 10.1039/C2CC30618B

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