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Issue 32, 2012
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A novel synthetic strategy for monosubstituted cyclodextrin derivatives

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Abstract

A first solid phase approach to obtain monosubstituted CD conjugates to different labels has been developed. A new solid support has been designed to get a variety of C-6 monofunctionalized CDs (α, β, MeβCD and HPβCD) covalently linked through a phosphodiester bridge to different labels, in highly pure form and under very mild detachment conditions.

Graphical abstract: A novel synthetic strategy for monosubstituted cyclodextrin derivatives

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Publication details

The article was received on 24 Jan 2012, accepted on 23 Feb 2012 and first published on 24 Feb 2012


Article type: Communication
DOI: 10.1039/C2CC30550J
Citation: Chem. Commun., 2012,48, 3875-3877

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    A novel synthetic strategy for monosubstituted cyclodextrin derivatives

    G. D. Fabio, G. Malgieri, C. Isernia, J. D'Onofrio, M. Gaglione, A. Messere, A. Zarrelli and L. De Napoli, Chem. Commun., 2012, 48, 3875
    DOI: 10.1039/C2CC30550J

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