Issue 30, 2012

Efficient dynamic kinetic resolution of racemic secondary alcohols by a chemoenzymatic system using bifunctional iridium complexes with C–N chelate amido ligands

Abstract

The combined catalyst system of bifunctional amidoiridium complexes derived from benzylic amines with CALB was found to provide a range of chiral acetates from racemic secondary alcohols in excellent yields with nearly perfect enantioselectivities via dynamic kinetic resolution.

Graphical abstract: Efficient dynamic kinetic resolution of racemic secondary alcohols by a chemoenzymatic system using bifunctional iridium complexes with C–N chelate amido ligands

  • This article is part of the themed collection: Chirality

Supplementary files

Article information

Article type
Communication
Submitted
15 Jan 2012
Accepted
15 Feb 2012
First published
17 Feb 2012

Chem. Commun., 2012,48, 3635-3637

Efficient dynamic kinetic resolution of racemic secondary alcohols by a chemoenzymatic system using bifunctional iridium complexes with C–N chelate amido ligands

Y. Sato, Y. Kayaki and T. Ikariya, Chem. Commun., 2012, 48, 3635 DOI: 10.1039/C2CC30333G

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