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Issue 21, 2012
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Thiolene reaction: a versatile tool in site-specific labelling of proteins with chemically inert tags for paramagnetic NMR

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Abstract

Site-specific tagging of proteins with paramagnetic lanthanides generates valuable long-range structure restraints for structural biology by NMR spectroscopy. We show that the thiol–ene addition reaction offers a powerful tool for tagging proteins in a chemically stable manner with very small lanthanide tags.

Graphical abstract: Thiol–ene reaction: a versatile tool in site-specific labelling of proteins with chemically inert tags for paramagnetic NMR

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Publication details

The article was received on 18 Dec 2011, accepted on 19 Jan 2012 and first published on 19 Jan 2012


Article type: Communication
DOI: 10.1039/C2CC17900H
Citation: Chem. Commun., 2012,48, 2704-2706

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    Thiolene reaction: a versatile tool in site-specific labelling of proteins with chemically inert tags for paramagnetic NMR

    Q. Li, Y. Yang, A. Maleckis, G. Otting and X. Su, Chem. Commun., 2012, 48, 2704
    DOI: 10.1039/C2CC17900H

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