Issue 34, 2012
From the journal:

Chemical Communications

A simple and effective strategy for labelingcysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes†

Jiang Qian,a   Revati Wani,a   Chananat Klomsiri,b   Leslie B. Poole,b   Allen W. Tsanga  and  Cristina M. Furdui*a  

* Corresponding authors

a Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, USA
E-mail: cfurdui@wakehealth.edu
Fax: +1 336 716-1214
Tel: +1 336 716-2697

b Department of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, USA

Abstract

β-ketoesters are robust probes for labeling sulfenic acid (–SOH) proteins allowing quantitative cleavage of the tag for improved analysis of the labeled peptides by MS.

Graphical abstract: A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes

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Article information

DOI
https://doi.org/10.1039/C2CC17868K
Article type
Communication
Submitted
16 Dec 2011
Accepted
17 Feb 2012
First published
20 Mar 2012

Chem. Commun., 2012,48, 4091-4093

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A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes

J. Qian, R. Wani, C. Klomsiri, L. B. Poole, A. W. Tsang and C. M. Furdui, Chem. Commun., 2012, 48, 4091 DOI: 10.1039/C2CC17868K

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