Issue 20, 2012

Efficient synthesis of isochromanones and isoquinolinesviaYb(OTf)3-catalyzed tandem oxirane/aziridine ring opening/Friedel–Crafts cyclization

Abstract

The first example of Yb(OTf)3-catalyzed tandem ring opening/Friedel–Crafts cyclization of oxiranyl and aziridinyl ketonesvia selective C–C bond cleavage under mild conditions was developed. Isochromanones and isoquinolines are formed in reasonable yields, which often serve as building blocks for complex chemical synthesis.

Graphical abstract: Efficient synthesis of isochromanones and isoquinolinesviaYb(OTf)3-catalyzed tandem oxirane/aziridine ring opening/Friedel–Crafts cyclization

Supplementary files

Article information

Article type
Communication
Submitted
14 Dec 2011
Accepted
17 Jan 2012
First published
18 Jan 2012

Chem. Commun., 2012,48, 2636-2638

Efficient synthesis of isochromanones and isoquinolinesviaYb(OTf)3-catalyzed tandem oxirane/aziridine ring opening/Friedel–Crafts cyclization

L. Wei and J. Zhang, Chem. Commun., 2012, 48, 2636 DOI: 10.1039/C2CC17836B

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