Issue 14, 2012

Efficient iron(iii)-catalyzed three-component coupling reaction of alkynes, CH2Cl2 and amines to propargylamines

Abstract

An iron(III)-catalyzed three-component coupling reaction of alkynes, CH2Cl2 and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situFT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C–H bond activation of alkynes thanks to cooperative effect of FeCl3 and 1,1,3,3-tetramethylguanidine.

Graphical abstract: Efficient iron(iii)-catalyzed three-component coupling reaction of alkynes, CH2Cl2 and amines to propargylamines

Supplementary files

Article information

Article type
Communication
Submitted
06 Dec 2011
Accepted
14 Dec 2011
First published
20 Dec 2011

Chem. Commun., 2012,48, 2024-2026

Efficient iron(III)-catalyzed three-component coupling reaction of alkynes, CH2Cl2 and amines to propargylamines

J. Gao, Q. Song, L. He, Z. Yang and X. Dou, Chem. Commun., 2012, 48, 2024 DOI: 10.1039/C2CC17616E

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