Fibrillisation of ring-closed amyloid peptides

Abstract

Ring-closing olefin metathesis reactions are used to create intra-molecularly ring closed peptides or inter-molecularly ring-closed peptide dimers based on a designed amyloid peptide sequence. The uncrosslinked peptide self-assembles into high aspect ratio nanotubes, however ring-closing leads to the formation of fibrillar and twisted/helical ribbon structures.