Issue 31, 2012
From the journal:

Chemical Communications

Rapid, non-targeted discovery of biochemical transformation and biomarker candidates in oncovirus-infected cell lines using LAESI mass spectrometry†

Bindesh Shrestha,a   Prabhakar Sripadi,a   Callee M. Walsh,b   Trust T. Razunguzwa,b   Matthew J. Powell,b   Kylene Kehn-Hall,c   Fatah Kashanchic  and  Akos Vertes*a  

* Corresponding authors

a Department of Chemistry, W. M. Keck Institute of Proteomics Technology and Applications, The George Washington University, Washington D.C, USA
E-mail: vertes@gwu.edu
Fax: +1-202-994-5873
Tel: +1-202-994-2717

b Protea Biosciences, 955 Hartman Run Road, Morgantown

c Department of Molecular and Microbiology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, USA

Abstract

Finding insights into how viruses hijack metabolic processes and biomarkers for viral diseases often require hypotheses about target compounds and/or labelling techniques. Here we present a method based on laser ablation electrospray ionization mass spectrometry to rapidly identify potential protein and metabolite biomarkers of oncovirus infection in B lymphocytes.

Graphical abstract: Rapid, non-targeted discovery of biochemical transformation and biomarker candidates in oncovirus-infected cell lines using LAESI mass spectrometry

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Article information

DOI
https://doi.org/10.1039/C2CC17225A
Article type
Communication
Submitted
21 Nov 2011
Accepted
01 Dec 2011
First published
14 Dec 2011

Chem. Commun., 2012,48, 3700-3702

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Rapid, non-targeted discovery of biochemical transformation and biomarker candidates in oncovirus-infected cell lines using LAESI mass spectrometry

B. Shrestha, P. Sripadi, C. M. Walsh, T. T. Razunguzwa, M. J. Powell, K. Kehn-Hall, F. Kashanchi and A. Vertes, Chem. Commun., 2012, 48, 3700 DOI: 10.1039/C2CC17225A

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