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Issue 17, 2012
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A universal strategy for preparing protected C-terminal peptides on the solid phase through an intramolecular click chemistry-based handle

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Abstract

A new universal strategy exploits DKP formation in a dipeptide moiety whose C-terminal residue is blocked by a leaving group. It enables both synthesis of C-terminal protected peptides that are useful for convergent synthesis of large peptides and use of a C-terminal permanent protecting group that can be cleaved by catalytic hydrogenation to release the peptide.

Graphical abstract: A universal strategy for preparing protected C-terminal peptides on the solid phase through an intramolecular click chemistry-based handle

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Publication details

The article was received on 20 Nov 2011, accepted on 04 Jan 2012 and first published on 06 Jan 2012


Article type: Communication
DOI: 10.1039/C2CC17222D
Chem. Commun., 2012,48, 2313-2315

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    A universal strategy for preparing protected C-terminal peptides on the solid phase through an intramolecular click chemistry-based handle

    M. Góngora-Benítez, M. Cristau, M. Giraud, J. Tulla-Puche and F. Albericio, Chem. Commun., 2012, 48, 2313
    DOI: 10.1039/C2CC17222D

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