Jump to main content
Jump to site search

Issue 15, 2012
Previous Article Next Article

Interstrand cross-link of DNA by covalently linking a pair of abasic sites

Author affiliations

Abstract

A pair of apurinic/apyrimidinic sites formed in DNA has been covalently connected with bis(aminooxy) derivatives. The efficacy of the interstrand cross-link is associated with the structural tethering of two aminooxy groups. The interstrand cross-link constructed stable DNA scaffolds for enzyme alignment.

Graphical abstract: Interstrand cross-link of DNA by covalently linking a pair of abasic sites

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Nov 2011, accepted on 23 Dec 2011 and first published on 04 Jan 2012


Article type: Communication
DOI: 10.1039/C2CC16785A
Citation: Chem. Commun., 2012,48, 2143-2145

  •   Request permissions

    Interstrand cross-link of DNA by covalently linking a pair of abasic sites

    K. Ichikawa, N. Kojima, Y. Hirano, T. Takebayashi, K. Kowata and Y. Komatsu, Chem. Commun., 2012, 48, 2143
    DOI: 10.1039/C2CC16785A

Search articles by author

Spotlight

Advertisements