Issue 15, 2012
From the journal:

Chemical Communications

Interstrand cross-link of DNA by covalently linking a pair of abasic sites†

Kohei Ichikawa,a   Naoshi Kojima,b   Yu Hirano,b   Toshie Takebayashi,b   Keiko Kowatab  and  Yasuo Komatsu*b  

* Corresponding authors

a Nippon Steel Kankyo Engineering Co. Ltd., 2-1-38 Shiohama, Kisarazu 292-0838, Japan

b Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-2-1 Tsukisamu-Higashi, Toyohira-ku, Sapporo 062-8517, Japan
E-mail: komatsu-yasuo@aist.go.jp

Abstract

A pair of apurinic/apyrimidinic sites formed in DNA has been covalently connected with bis(aminooxy) derivatives. The efficacy of the interstrand cross-link is associated with the structural tethering of two aminooxy groups. The interstrand cross-link constructed stable DNA scaffolds for enzyme alignment.

Graphical abstract: Interstrand cross-link of DNA by covalently linking a pair of abasic sites

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC16785A
Article type
Communication
Submitted
02 Nov 2011
Accepted
23 Dec 2011
First published
04 Jan 2012

Chem. Commun., 2012,48, 2143-2145

Permissions

Request permissions

Interstrand cross-link of DNA by covalently linking a pair of abasic sites

K. Ichikawa, N. Kojima, Y. Hirano, T. Takebayashi, K. Kowata and Y. Komatsu, Chem. Commun., 2012, 48, 2143 DOI: 10.1039/C2CC16785A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements