Based on photocrosslinkable PEGDMA and GelMA hydrogels, two “bottom-up” approaches (“circle-and-cross” and “layer-by-layer”) were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the “layer-by-layer” approach employing the GelMA hydrogel with a higher biocompatibility was more favorable for building biomimetic osteon.
Y. Zuo, W. Xiao, X. Chen, Y. Tang, H. Luo and H. Fan, Chem. Commun., 2012, 48, 3170 DOI: 10.1039/C2CC16744A
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