Issue 21, 2012
From the journal:

Chemical Communications

A chromenoquinoline-based fluorescent off–onthiol probe for bioimaging†

Dnyaneshwar Kand,a   Arunasree Marasanapalli Kalle,b   Sreejith Jayasree Varmaa  and  Pinaki Talukdar*a  

* Corresponding authors

a Department of Chemistry, Dmitri Mendeleev Block, Indian Institute of Science Education and Research Pune, India
E-mail: ptalukdar@iiserpune.ac.in
Fax: +91 20 2589 9790
Tel: +91 20 2590 8001

b Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad, India

Abstract

A new chromenoquinoline-based fluorescent off–onthiol probe 2 is reported. In aqueous buffer solutions at physiological pH, the probe exhibited 223-fold enhancement in fluorescence intensity by a Michael addition of cysteine to the maleimide appended to a chromenoquinoline. Cell permeability and live cell imaging of thiols are also demonstrated.

Graphical abstract: A chromenoquinoline-based fluorescent off–onthiol probe for bioimaging

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Article information

DOI
https://doi.org/10.1039/C2CC16593G
Article type
Communication
Submitted
24 Oct 2011
Accepted
19 Jan 2012
First published
19 Jan 2012

Chem. Commun., 2012,48, 2722-2724

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A chromenoquinoline-based fluorescent off–onthiol probe for bioimaging

D. Kand, A. M. Kalle, S. J. Varma and P. Talukdar, Chem. Commun., 2012, 48, 2722 DOI: 10.1039/C2CC16593G

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