Issue 5, 2012
From the journal:

Chemical Communications

Introducing chemiluminescence resonance energy transfer into immunoassay in a microfluidic format for an improved assay sensitivity†

Shulin Zhao,*a   Jinwen Liu,a   Yong Huanga  and  Yi-Ming Liu*b  

* Corresponding authors

a Ministry of Education Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, China
E-mail: zhaoshulin001@163.com
Fax: +86 773-583-2294
Tel: +86 773 5856104

b Department of Chemistry and Biochemistry, Jackson State University, 1400 Lynch St., Jackson, USA
E-mail: yiming.liu@jsums.edu
Fax: +1-601-979-3674
Tel: +1-601-979-3491

Abstract

We report on a novel strategy to improve microfluidic immunoassay sensitivity by introducing chemiluminescence resonance energy transfer (CRET) into the immunoreactions. The proposed CRET-based immunoassay for estradiol (E2, as a model analyte) is one of the most sensitive immunoassay with a limit of detection at 3.6 × 10−11 M E2 in a microfluidic format.

Graphical abstract: Introducing chemiluminescence resonance energy transfer into immunoassay in a microfluidic format for an improved assay sensitivity

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Article information

DOI
https://doi.org/10.1039/C1CC16435J
Article type
Communication
Submitted
17 Oct 2011
Accepted
20 Nov 2011
First published
21 Nov 2011

Chem. Commun., 2012,48, 699-701

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Introducing chemiluminescence resonance energy transfer into immunoassay in a microfluidic format for an improved assay sensitivity

S. Zhao, J. Liu, Y. Huang and Y. Liu, Chem. Commun., 2012, 48, 699 DOI: 10.1039/C1CC16435J

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