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Issue 4, 2012
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Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis

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Abstract

Cleavage agents showed cleavage yields as much as 9–14%, which does not sufficiently support the agents' protection of β-cells from the cytotoxicity of h-IAPP. INS-1 cell tests were carried out to better understand the potential of using these cleavage agents as drug candidates. This study provides the firm basis for clinical applicability of these cleavage agents.

Graphical abstract: Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis

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Article information


Submitted
10 Oct 2011
Accepted
11 Nov 2011
First published
23 Nov 2011

Chem. Commun., 2012,48, 588-590
Article type
Communication

Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis

K. Jeong, H. R. Cho, S. H. Choi, Y. Park and P. S. Chae, Chem. Commun., 2012, 48, 588
DOI: 10.1039/C1CC16293D

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