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Issue 4, 2012
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Design of a multinuclear Zn(II) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins

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Abstract

A Zn(II) complex (Zn(II)–Ida) was designed as the new fluorescent probe for His-tag fused proteins. Thanks to the tight binding ability to histidine-rich sequences and bright fluorescence property of the Cy5-appended Zn(II)–Ida probes, selective and clear fluorescent imaging of the His-tag fused G-protein coupled receptors on live cell surfaces was carried out.

Graphical abstract: Design of a multinuclear Zn(ii) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins

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Publication details

The article was received on 08 Oct 2011, accepted on 11 Nov 2011 and first published on 15 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16263B
Citation: Chem. Commun., 2012,48, 594-596

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    Design of a multinuclear Zn(II) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins

    S. Fujishima, H. Nonaka, S. Uchinomiya, Y. Alex. Kawase, A. Ojida and I. Hamachi, Chem. Commun., 2012, 48, 594
    DOI: 10.1039/C1CC16263B

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