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Issue 10, 2012

Nucleobase recognition at alkaline pH and apparent pKa of single DNA bases immobilised within a biological nanopore

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Abstract

The four DNA bases are recognized in immobilized DNA strands at high alkaline pH by nanopore current recordings. Ionic currents through the biological nanopores are also employed to measure the apparent pKa values of single nucleobases within the immobilised DNA strands.

Graphical abstract: Nucleobase recognition at alkaline pH and apparent pKa of single DNA bases immobilised within a biological nanopore

Supplementary files

Article information


Submitted
01 Oct 2011
Accepted
07 Nov 2011
First published
17 Nov 2011

Chem. Commun., 2012,48, 1520-1522
Article type
Communication

Nucleobase recognition at alkaline pH and apparent pKa of single DNA bases immobilised within a biological nanopore

L. Franceschini, E. Mikhailova, H. Bayley and G. Maglia, Chem. Commun., 2012, 48, 1520 DOI: 10.1039/C1CC16124E

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