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Issue 2, 2012
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Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides

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Abstract

A protocol for the Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides that minimizes protodeboronation is described. A combination of catalytic amounts of Pd(OAc)2 and SPhos in conjunction with CsF in isopropanol effectively affords a variety of coupled products. Surprisingly, a dramatic temperature dependence in product selectivity was observed.

Graphical abstract: Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides

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Publication details

The article was received on 26 Sep 2011, accepted on 28 Oct 2011 and first published on 14 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC15990A
Citation: Chem. Commun., 2012,48, 203-205
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    Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides

    A. Thakur, K. Zhang and J. Louie, Chem. Commun., 2012, 48, 203
    DOI: 10.1039/C1CC15990A

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