Apoferritin–CeO2 nano-truffle that has excellent artificial redox enzyme activity

Xiangyou Liu; Wei Wei; Quan Yuan; Xin Zhang; Ning Li; Yuguang Du; Guanghui Ma; Chunhua Yan; Ding Ma

doi:10.1039/C1CC15815E

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Apoferritin–CeO₂ nano-truffle that has excellent artificial redox enzyme activity†

Xiangyou Liu,‡^ab Wei Wei,‡^c Quan Yuan,^a Xin Zhang,^d Ning Li,^e Yuguang Du,^b Guanghui Ma,^c Chunhua Yan^a and Ding Ma*^a

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
E-mail: dma@pku.edu.cn
Fax: +86-10-62758603
Tel: +86-10-62758603

^b Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

^c National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100, China

^d Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, USA

^e Lab of Applied Biocatalysis, South China University of Technology, Guangzhou 510640, China

Abstract

4.5 nm nanoceria particles are successfully encapsulated into the apoferritin cavity via a dissociation–reconstruction route. The apoferritin coating not only improves the biocompatibility and changes the cellular uptake route of nanoceria, but also manipulates the electron localization at the surface of the nanoparticle thereby ameliorating the ROS-scavenging activity.

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Article information

DOI: https://doi.org/10.1039/C1CC15815E
Article type: Communication
Submitted: 20 Sep 2011
Accepted: 01 Nov 2011
First published: 01 Dec 2011

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Chem. Commun., 2012,48, 3155-3157

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Apoferritin–CeO₂ nano-truffle that has excellent artificial redox enzyme activity

X. Liu, W. Wei, Q. Yuan, X. Zhang, N. Li, Y. Du, G. Ma, C. Yan and D. Ma, Chem. Commun., 2012, 48, 3155 DOI: 10.1039/C1CC15815E

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