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Issue 10, 2012
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Modular synthesis of supramolecular ureidopyrimidinone–peptide conjugates using an oxime ligation strategy

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Abstract

A convenient method to prepare supramolecular bioconjugates in a facile and scalable manner is by a modular approach, whereby self-assembling units and peptides are coupled using oxime chemistry. We here report syntheses of bioactive ureidopyrimidinone-based peptide conjugates, and their resultant self-assembly into fibrous structures.

Graphical abstract: Modular synthesis of supramolecular ureidopyrimidinone–peptide conjugates using an oxime ligation strategy

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Supplementary files

Article information


Submitted
31 Jul 2011
Accepted
07 Oct 2011
First published
18 Oct 2011

Chem. Commun., 2012,48, 1452-1454
Article type
Communication

Modular synthesis of supramolecular ureidopyrimidinonepeptide conjugates using an oxime ligation strategy

R. E. Kieltyka, M. M. C. Bastings, G. C. van Almen, P. Besenius, E. W. L. Kemps and P. Y. W. Dankers, Chem. Commun., 2012, 48, 1452 DOI: 10.1039/C1CC14728E

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