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Issue 10, 2012

Facile synthesis and altered ionization efficiency of diverse Nε-alkyllysine-containing peptides

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Abstract

Protein lysine methylation is a biologically-important posttranslational modification. Given the increased use of alkyllysine-containing peptides to study protein methylation, we describe an efficient solid-phase synthesis to access various alkyllysine-containing peptides. As an exemplary application, we evaluated how ionization efficiency of the alkyllysine peptides affects mass spectrometric analysis.

Graphical abstract: Facile synthesis and altered ionization efficiency of diverse Nε-alkyllysine-containing peptides

Supplementary files

Article information


Submitted
31 Jul 2011
Accepted
19 Sep 2011
First published
30 Sep 2011

Chem. Commun., 2012,48, 1514-1516
Article type
Communication

Facile synthesis and altered ionization efficiency of diverse Nε-alkyllysine-containing peptides

D. Chakraborty, K. Islam and M. Luo, Chem. Commun., 2012, 48, 1514 DOI: 10.1039/C1CC14711K

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