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Issue 10, 2012

Thioamide quenching of intrinsic protein fluorescence

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Abstract

Thioamides quench tryptophan and tyrosine fluorescence in a distance-dependent manner and thus can be used to monitor the binding of thioamide-containing peptides to proteins. Since thioamide analogs of the natural amino acids can be synthetically incorporated into peptides, they can function as minimally-perturbing probes of protein/peptide interactions.

Graphical abstract: Thioamide quenching of intrinsic protein fluorescence

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Supplementary files

Article information


Submitted
31 Jul 2011
Accepted
25 Aug 2011
First published
12 Sep 2011

Chem. Commun., 2012,48, 1550-1552
Article type
Communication

Thioamide quenching of intrinsic protein fluorescence

J. M. Goldberg, R. F. Wissner, A. M. Klein and E. J. Petersson, Chem. Commun., 2012, 48, 1550 DOI: 10.1039/C1CC14708K

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