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Issue 4, 2012
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Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

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Abstract

A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at killing the HepG2 cells over BSH.

Graphical abstract: Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

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Publication details

The article was received on 21 Jul 2011, accepted on 07 Nov 2011 and first published on 23 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC14447B
Chem. Commun., 2012,48, 612-614

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    Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

    C. Lai, Y. Lin, F. Chou, C. Liang, E. Lin, Y. Chuang and C. Lin, Chem. Commun., 2012, 48, 612
    DOI: 10.1039/C1CC14447B

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