Jump to main content
Jump to site search

Issue 10, 2012

Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

Author affiliations

Abstract

Macrocyclic Organo-Peptide Hybrids (MOrPHs) can be prepared from genetically encoded polypeptidesvia a chemoselective and catalyst-free reaction between a trifunctional oxyamino/amino-thiol synthetic precursor and an intein-fusion protein incorporating a bioorthogonal keto group.

Graphical abstract: Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

Supplementary files

Article information


Submitted
15 Jun 2011
Accepted
11 Aug 2011
First published
07 Sep 2011

Chem. Commun., 2012,48, 1461-1463
Article type
Communication

Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

M. Satyanarayana, F. Vitali, J. R. Frost and R. Fasan, Chem. Commun., 2012, 48, 1461 DOI: 10.1039/C1CC13533C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements