Atom arrangement strategy for designing a turn-on 1H magnetic resonance probe: a dual activatable probe for multimodal detection of hypochlorite

Abstract

The first dual activatable hypochlorite (⁻OCl)-sensing probe was developed, based on a new proof-of-concept design involving signal-activatable ¹H chemical probes using the triple-resonance NMR technique. The probe enabled fluorescence–¹H MR dual turn-on detection of⁻OCl in solution and in crude tissue extracts.