Issue 39, 2011
From the journal:

Chemical Communications

Coupling of ortho-substituted aryl chlorides with bulky amides†

Florian C. Falk,a   Roland Fröhlichb  and  Jan Paradies*a  

* Corresponding authors

a Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, D-76131 Karlsruhe, Germany
E-mail: jan.paradies@kit.edu
Fax: +49 721 608 5637
Tel: +49 721 608 5344

b Institute of Organic Chemistry, University of Münster, Corrensstrasse 40, D-48149 Münster, Germany
E-mail: frohlic@uni-muenster.de
Fax: +49 251 83 39772
Tel: +49 251 83 33293

Abstract

Voluminous amides were coupled with deactivated, sterically hindered aryl chlorides in excellent yields providing products, which have not been efficiently accessible by transition metal catalysis so far. Application of an unsymmetric bisphosphine ligand was critical for the high catalytic activity.

Graphical abstract: Coupling of ortho-substituted aryl chlorides with bulky amides

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Article information

DOI
https://doi.org/10.1039/C1CC14844C
Article type
Communication
Submitted
05 Aug 2011
Accepted
01 Sep 2011
First published
12 Sep 2011

Chem. Commun., 2011,47, 11095-11097

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Coupling of ortho-substituted aryl chlorides with bulky amides

F. C. Falk, R. Fröhlich and J. Paradies, Chem. Commun., 2011, 47, 11095 DOI: 10.1039/C1CC14844C

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