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Issue 40, 2011
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5-Hydroxymethylcytosine-selective oxidation with peroxotungstate

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Tungsten oxidation worked as a simple chemical reaction for the effective detection of 5-hydroxymethylcytosine in DNA, distinguishing it from its epigenetic precursors, 5-methylcytosine and unmethylated cytosine. The tungsten-oxidation product obtained from 5-hydroxymethylcytosine was trihydroxylated thymine and was detected as a cleavage band in gel electrophoresis after treatment with hot piperidine.

Graphical abstract: 5-Hydroxymethylcytosine-selective oxidation with peroxotungstate

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The article was received on 03 Aug 2011, accepted on 19 Aug 2011 and first published on 15 Sep 2011

Article type: Communication
DOI: 10.1039/C1CC14782J
Chem. Commun., 2011,47, 11231-11233

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    5-Hydroxymethylcytosine-selective oxidation with peroxotungstate

    A. Okamoto, K. Sugizaki, A. Nakamura, H. Yanagisawa and S. Ikeda, Chem. Commun., 2011, 47, 11231
    DOI: 10.1039/C1CC14782J

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