Issue 44, 2011
From the journal:

Chemical Communications

Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity†

Youhong Niu,‡a   Shruti Padhee,‡a   Haifan Wu,a   Ge Bai,a   Lacey Harrington,b   Whittney N. Burda,b   Lindsey N. Shaw,b   Chuanhai Caoc  and  Jianfeng Cai*a  

* Corresponding authors

a Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA
E-mail: jianfengcai@usf.edu
Fax: +1-813-974-3203
Tel: +1-813-974-9506

b Department of Cell Biology, Microbiology and Molecular Biology, 4202 E. Fowler Ave, Tampa, FL 33620, USA

c Department of Molecular Pharmacology and Physiology, USF-Health Byrd Alzheimer's Institute, 4001 E. Fletcher Ave, Tampa, FL 33613, USA

Abstract

We report the identification of a new class of antimicrobial peptidomimetics-γ-AApeptides with potent and broad-spectrum activity, including clinically-relevant strains that are unresponsive to most antibiotics. They are also not prone to select for drug-resistance.

Graphical abstract: Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity

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Article information

DOI
https://doi.org/10.1039/C1CC14476F
Article type
Communication
Submitted
22 Jul 2011
Accepted
19 Sep 2011
First published
03 Oct 2011

Chem. Commun., 2011,47, 12197-12199

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Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity

Y. Niu, S. Padhee, H. Wu, G. Bai, L. Harrington, W. N. Burda, L. N. Shaw, C. Cao and J. Cai, Chem. Commun., 2011, 47, 12197 DOI: 10.1039/C1CC14476F

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