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Issue 41, 2011
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Sultone opening with [18F]fluoride: an efficient 18F-labelling strategy for PET imaging

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Abstract

Sultones were subject to ring opening by nucleophilic attack with [18F]fluoride to afford easily purified 18F-labelled hydrophilic sulfonated products in high yields. A two-step sequence including radiofluorination and coupling to lysine was then developed from a bis-sultone precursor as a model approach for the labelling of biopolymers.

Graphical abstract: Sultone opening with [18F]fluoride: an efficient 18F-labelling strategy for PET imaging

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Publication details

The article was received on 21 Jul 2011, accepted on 13 Sep 2011 and first published on 26 Sep 2011


Article type: Communication
DOI: 10.1039/C1CC14435A
Citation: Chem. Commun., 2011,47, 11465-11467

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    Sultone opening with [18F]fluoride: an efficient 18F-labelling strategy for PET imaging

    S. Schmitt, C. Bouteiller, L. Barré and C. Perrio, Chem. Commun., 2011, 47, 11465
    DOI: 10.1039/C1CC14435A

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