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Issue 48, 2011
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A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

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Abstract

We demonstrated the importance of maximized skeletal diversity of privileged substructures for the construction of a drug-like small-molecule library through a series of high-throughput screening and subsequent bioevaluations. Our divergent pDOS strategy can provide an efficient approach for the discovery of novel small-molecule modulators with excellent specificity.

Graphical abstract: A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

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Article information


Submitted
06 Jul 2011
Accepted
08 Aug 2011
First published
25 Aug 2011

Chem. Commun., 2011,47, 12754-12761
Article type
Feature Article

A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

S. Oh and S. B. Park, Chem. Commun., 2011, 47, 12754
DOI: 10.1039/C1CC14042F

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