Issue 48, 2011
From the journal:

Chemical Communications

A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

Sangmi Oh†a  and  Seung Bum Park*ab  

* Corresponding authors

a Department of Chemistry, Seoul National University, Seoul 151-747, Korea
E-mail: sbpark@snu.ac.kr
Fax: +82-2-884-8025
Tel: +82-2-880-9090

b Department of Biophysics and Chemical Biology, Seoul National University, Seoul 151-727, Korea

Abstract

We demonstrated the importance of maximized skeletal diversity of privileged substructures for the construction of a drug-like small-molecule library through a series of high-throughput screening and subsequent bioevaluations. Our divergent pDOS strategy can provide an efficient approach for the discovery of novel small-molecule modulators with excellent specificity.

Graphical abstract: A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

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Article information

DOI
https://doi.org/10.1039/C1CC14042F
Article type
Feature Article
Submitted
06 Jul 2011
Accepted
08 Aug 2011
First published
25 Aug 2011

Chem. Commun., 2011,47, 12754-12761

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A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

S. Oh and S. B. Park, Chem. Commun., 2011, 47, 12754 DOI: 10.1039/C1CC14042F

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