Issue 38, 2011

A synthetic approach to kingianin A based on biosynthetic speculation

Abstract

A synthetic approach towards the structurally complex dimer, kingianin A is reported. The strategy involved a cascade of complexity generating reactions, inspired through biosynthetic speculation. A concise protecting group free synthesis of the proposed monomeric precursor pre-kingianin A has been achieved using a tandem Stille cross-coupling reaction and electrocyclisation process. However, preliminary studies of the key dimerisation reaction have been conducted, which indicate that the process is not spontaneous, raising questions as to the origin of this complex natural product.

Graphical abstract: A synthetic approach to kingianin A based on biosynthetic speculation

Supplementary files

Article information

Article type
Communication
Submitted
01 Jul 2011
Accepted
05 Aug 2011
First published
24 Aug 2011

Chem. Commun., 2011,47, 10605-10607

A synthetic approach to kingianin A based on biosynthetic speculation

P. Sharma, D. J. Ritson, J. Burnley and J. E. Moses, Chem. Commun., 2011, 47, 10605 DOI: 10.1039/C1CC13949E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements