Issue 34, 2011

Unsymmetrical β-cyclodextrin-conjugated silicon(iv) phthalocyanines as highly potent photosensitisers for photodynamic therapy

Abstract

A series of unsymmetrical silicon(IV) phthalocyanines with a permethylated β-cyclodextrin unit and a sugar or a diamino moiety as the axial substituents have been prepared. These compounds are highly photocytotoxic with IC50 values as low as 21 nM, which is ca. sevenfold lower than those of the symmetrical bis(cyclodextrin) analogue.

Graphical abstract: Unsymmetrical β-cyclodextrin-conjugated silicon(iv) phthalocyanines as highly potent photosensitisers for photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
24 Jun 2011
Accepted
07 Jul 2011
First published
29 Jul 2011

Chem. Commun., 2011,47, 9657-9659

Unsymmetrical β-cyclodextrin-conjugated silicon(IV) phthalocyanines as highly potent photosensitisers for photodynamic therapy

J. T. F. Lau, P. Lo, Y. Tsang, W. Fong and D. K. P. Ng, Chem. Commun., 2011, 47, 9657 DOI: 10.1039/C1CC13783B

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