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Issue 36, 2011
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Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

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Abstract

The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

Graphical abstract: Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

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Publication details

The article was received on 16 Jun 2011, accepted on 22 Jul 2011 and first published on 10 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC13597J
Chem. Commun., 2011,47, 10025-10027

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    Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ

    M. A. DeSieno, W. A. van der Donk and H. Zhao, Chem. Commun., 2011, 47, 10025
    DOI: 10.1039/C1CC13597J

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