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Issue 35, 2011
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Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting

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Abstract

The function of cell-specific ligands on gold nanoparticles can be selectively gated by the action of co-grafted thermosensitive polymers. Below the LCST the responsive chain-extended polymers prevent cell-surface receptors from accessing the affinity ligands while above the LCST, the polymers collapse exposing the ligands and allowing binding to receptors, which in turn promotes cell internalisation.

Graphical abstract: Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting

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Supplementary files

Article information


Submitted
05 May 2011
Accepted
15 Jul 2011
First published
02 Aug 2011

Chem. Commun., 2011,47, 9846-9848
Article type
Communication

Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting

F. Mastrotto, P. Caliceti, V. Amendola, S. Bersani, J. P. Magnusson, M. Meneghetti, G. Mantovani, C. Alexander and S. Salmaso, Chem. Commun., 2011, 47, 9846
DOI: 10.1039/C1CC12654G

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