Issue 25, 2011
From the journal:

Chemical Communications

Total synthesis of a 20-deoxybryostatin†

Anthony P. Green,a   Alan T. L. Leea  and  Eric J. Thomas*a  

* Corresponding authors

a School of Chemistry, University of Manchester, Manchester, UK
E-mail: e.j.thomas@manchester.ac.uk
Fax: 00 44 (0)161 275 4939
Tel: 00 44 (0)161 275 4614

Abstract

The 20-deoxybryostatin 40 has been prepared using a modified Julia olefination to form the 16,17-double-bond, followed by macrolactonisation, selective deprotection and oxidation. This is the first total synthesis of a 20-deoxybryostatin.

Graphical abstract: Total synthesis of a 20-deoxybryostatin

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Article information

DOI
https://doi.org/10.1039/C1CC12332G
Article type
Communication
Submitted
21 Apr 2011
Accepted
27 Apr 2011
First published
26 May 2011

Chem. Commun., 2011,47, 7200-7202

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Total synthesis of a 20-deoxybryostatin

A. P. Green, A. T. L. Lee and E. J. Thomas, Chem. Commun., 2011, 47, 7200 DOI: 10.1039/C1CC12332G

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