Issue 27, 2011
From the journal:

Chemical Communications

Highly enantioselective yttrium(iii)-catalyzed Friedel–Crafts alkylation of β-trichloro(trifluoro)methyl arylenones with indoles†

Wentao Wang,a   Xiangjin Lian,a   Donghui Chen,a   Xiaohua Liu,a   Lili Lina  and  Xiaoming Feng*a  

* Corresponding authors

a Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
E-mail: xmfeng@scu.edu.cn
Fax: +86 28-8541-8249

Abstract

An efficient yttrium(III)-catalyzed highly enantioselective Friedel–Crafts alkylation of β-trichloro(trifluoro)methyl aryl enones is described. The reaction delivered a series of functionalized indoles with a chiral tertiary carbon center bearing a trichloro(trifluoro)methyl group in excellent results (up to 96% ee and 99% yield) under mild conditions.

Graphical abstract: Highly enantioselective yttrium(iii)-catalyzed Friedel–Crafts alkylation of β-trichloro(trifluoro)methyl aryl enones with indoles

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Article information

DOI
https://doi.org/10.1039/C1CC12306H
Article type
Communication
Submitted
20 Apr 2011
Accepted
20 May 2011
First published
08 Jun 2011

Chem. Commun., 2011,47, 7821-7823

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Highly enantioselective yttrium(III)-catalyzed Friedel–Crafts alkylation of β-trichloro(trifluoro)methyl aryl enones with indoles

W. Wang, X. Lian, D. Chen, X. Liu, L. Lin and X. Feng, Chem. Commun., 2011, 47, 7821 DOI: 10.1039/C1CC12306H

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