Issue 32, 2011
From the journal:

Chemical Communications

Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization†

Toshimasa Hamamoto,a   Masahiko Sisido,a   Takashi Ohtsukia  and  Masumi Taki*a  

* Corresponding authors

a Department of Medical and Bioengineering Science, Chemical Biology Area, Division of Chemistry and Biochemistry, Okayama University, 1-1-1, Tsushimanaka, Okayama, Japan
E-mail: taki@biotech.okayama-u.ac.jp
Fax: +81-86-251-8021
Tel: +81-86-251-8218

Abstract

By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.

Graphical abstract: Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

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Article information

DOI
https://doi.org/10.1039/C1CC12196K
Article type
Communication
Submitted
16 Apr 2011
Accepted
23 Jun 2011
First published
07 Jul 2011

Chem. Commun., 2011,47, 9116-9118

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Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

T. Hamamoto, M. Sisido, T. Ohtsuki and M. Taki, Chem. Commun., 2011, 47, 9116 DOI: 10.1039/C1CC12196K

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