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Issue 29, 2011
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Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine by a chemically designed peptide

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Abstract

An artificial phosphopeptide recognized the difference between methylated and hydroxymethylated cytosines in DNA. The Sp1 zinc finger peptide substituted by phosphotyrosine effectively discriminated between 5-methylcytosine, 5-hydroxymethylcytosine (hmC) and unmethylated cytosine. The DNA recognition properties of the peptide differ from those of other chemicals that detect hmC.

Graphical abstract: Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine by a chemically designed peptide

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Article information


Submitted
14 Apr 2011
Accepted
03 Jun 2011
First published
21 Jun 2011

Chem. Commun., 2011,47, 8277-8279
Article type
Communication

Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine by a chemically designed peptide

A. Nomura, K. Sugizaki, H. Yanagisawa and A. Okamoto, Chem. Commun., 2011, 47, 8277
DOI: 10.1039/C1CC12131F

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